Waterfall Scientific
Waterfall Scientific is at the forefront of mRNA manufacturing, dedicated to accelerating breakthroughs in mRNA therapeutics, gene editing, and synthetic biology. Our proprietary continuous-flow synthesis technology ensures high-purity mRNA production, minimizing immunogenicity and enhancing therapeutic efficacy.
About Us
Founded in 2022, Waterfall Scientific (formerly RNA4Tx, Inc.) is a privately held biotechnology company based in Worcester, Massachusetts. Our mission is to manufacture high-quality custom mRNAs that accelerate groundbreaking research in mRNA therapeutics, gene editing, and beyond.
Our Team
- Inna Shcherbakova, PhD. – Chief Executive Officer
- Craig T Martin, PhD. – President & Chief Scientific Officer
- Melissa Moore, PhD. – Chair, Board of Directors
- Sarah Perry, PhD. – Co-Founder; Chair, Technical Advisory Board
Our leadership team brings decades of experience in mRNA biology, chemistry, and biomanufacturing, driving innovation in mRNA synthesis technologies.
Services
Custom mRNA Synthesis
At Waterfall Scientific, we specialize in continuous-flow mRNA manufacturing. Our advanced technology delivers high-purity, low-immunogenicity mRNA for use in therapeutics, vaccines, and synthetic biology applications. We provide custom synthesis, process optimization, and scale-up solutions tailored to your needs.
Custom mRNA Synthesis
We offer bespoke mRNA synthesis services tailored to your research and therapeutic needs, ensuring high-quality, consistent, and scalable production.
Comprehensive mRNA Characterization:
We provide rigorous characterization of your mRNA to ensure purity and integrity. Our analytical services include capillary electrophoresis, endotoxin testing, dsRNA quantification, residual analysis, poly(A) tail length determination, and capping efficiency measurement, among other assays tailored to your needs.
Collaborative Development
Waterfall Scientific actively seeks collaborations with industry leaders to further develop and broaden the application of our technology.
Technology
Continuous-Flow mRNA Manufacturing
Traditional batch mRNA manufacturing often results in double-stranded mRNA (dsRNA) contaminants, triggering unwanted immune responses. Our continuous-flow approach to mRNA synthesis dramatically increases yield and purity per template DNA, effectively eliminating immunogenicity before purification.
High Purity
By preventing dsRNA formation at the outset, we achieve near-zero detectable levels of dsRNA, reducing the need for extensive purification.
Scalability
Our fluidics system scales efficiently, accommodating both high-volume therapeutic production and personalized medicine applications.
Cost-Effectiveness
Continuous-flow manufacturing reduces production costs, making mRNA therapeutics more accessible.
Solutions
At Waterfall Scientific, we deliver cutting-edge solutions that simplify, accelerate, and enhance every step of mRNA manufacturing. From early-stage R&D to clinical-grade production, our proprietary continuous-flow synthesis platform enables unparalleled control, purity, and scalability.
Custom mRNA Synthesis
Flexible. Fast. High Fidelity.
We offer tailored synthesis of messenger mRNA constructs to meet your specific sequence, modification, and delivery needs. Our optimized protocols ensure high purity and low immunogenicity
Process Development & Optimization
Smart Scale-Out, Scaling Your mRNA Production for the Clinic:
When you’re prepared to move beyond research-grade mRNA, we assist in optimizing your manufacturing workflow. Our goal is to ensure your process is ready for efficient and compliant clinical-scale production.
Technology Licensing
Empower Your mRNA Program.
License our proprietary mRNA manufacturing technology to bring next-gen capabilities in-house. We provide full onboarding, tech transfer, and continued support.
Strategic Partnerships
Accelerate Innovation Together.
We actively collaborate with biotech firms, academic labs, and pharma partners to co-develop mRNA-based solutions for global health challenges.
Follow Us
- 17 Briden Street, Worcester, MA 01605, USA
- support@waterfallsci.com
- +1-774-502-1758.